The need for multi-scale technologies and multi-disciplinary research is an emerging paradigm in the understanding and engineering of the human tissue/organ system for regenerative medicine. For instance, cell and extracellular matrix interact via integrin binding at nanoscale while 3D culture is obtained by assembling cells and scaffold at microscale or mesoscale. Integration of these multiscale procedures is important for achieving the construction of functional tissues and organs that are appropriate for clinical use.

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Our long-term research goals include the following:

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• Decipher the role of cell-extracellular matrix interaction in tissue regeneration and stem cell differentiation

• Develop novel biomaterials and multiscale technologies for tissue engineering and regenerative medicine

• Develop microphysiological model for drug screening and disease modeling

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The following are the on-going projects in our lab:

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1. Microscale tissue engineering and organ-on-a-chip

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We are developing microscale fabrication strategies to construct complex tissue via a bottom-up approach for tissue/organ regeneration, in vitro disease modeling, and drug screening.​​​​

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2. Bioactive materials for tissue regeneration

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We are developing advanced biomaterial formulation to promote tissue regeneration.

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